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I don't know the answer to this, but my son is on the new med. Vyvanse for ADD. I was wondering this myself. How can a stimulant NOT affect their brain when used long term.?? I also tend to think that they are probably bi-polar and that it has been diagnosed as having ADD or ADHD because of their age. I know that, looking back, once I understood the disease it became clear to me how I suffered my whole life. Even when I was little. I feel that it is imperative that they do studies on this. But how can we get them (whoever them is) to do this? Great question hopeful mom.