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Hi, Susan. You answered your own question. Bipolar meds are notorious for causing weight gain. It doesn't really matter which ones, as we are all unique. Obviously, the Seroquel is having an adverse effect on you, and your pdoc needs to know this.   Excessive weight gain robs you of vitality, makes you sluggish, and causes loss of self-esteem. In short, it makes you feel worse, not better. Moreover it sets you up for diabetes and all manner of ills.   Many pdocs unconscionably assume that weight gain is a fair trade-off for mood stablization. If your pdoc feels this way, then find one who will listen to you.   In the meantime, you need to be proactive about your diet. Avoid fad diets, and work instead on modest goals based on eating sensibly. Often, you can satisfy your hunger pangs with low-fat, low-carb, healthy alternatives.