Hi,  Have you just tried lithium, alone?  I've been through the med gamit and it sucks, as well, as it doesn't work.  I was on lamictal and seroquel along with some anti aniexty meds.  Both drugs made me out of my mind for years, and the seroquel pushed me to the brink of diabetes.  Aweful.  I'm not sure what class of drugs your on but think about the impact on your daily life.  People consdered me weird, odd, unrelieable, and much more.  You know the syptoms.  I had two psychriastists tell me that this was good as my life would get, and that it was ashame since I had so much going for me.  I am tracking down those people.   I am none of those things-only with the drugs.  It was happenstance and me taking charge that I got off them.  Most people should.  If you question then go for it.  Do you want to continue down that path?   It will hurt, but I changed my diet, more sleep and natural supplements with lots of water.  Exercise is great help even if it's only walking a block or less.    I'm great now.  No more craziness, mild and infrequent mania, and that usually is from stress and missing a dose or two of lithium.  I feel great!  It's been 9 months now, but extremely worth the pain.   Good luck.  One more thing, good meaning docs throw meds at us.  Think of it this way-would you reinvent the wheel?  Simple is always good, and then proceed with caution if need be.  It might take time but in the greater scheme of things it's all realitive.  Thanks for listening and letting me chat!