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I was on Effexor XR for years and it eventually was making me too manic.   I switched to Wellbutrin for about 10 months but it did not do that job, i.e., I still had mild depression.  My doc has switched me to Pristiq about three months ago and it is working well.  No more   insomnia nor occasional manic attacks.  I am Bipolar i - rapid cycling.  Wotj Effexor I had more rapid cyclig also .  It is also  my understanding that Pristiq is easier on the liger.  gjmichele
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