In part one of this sharepost on women and bipolar, I highlighted the fact that gender differences exist most notably in the significantly higher rate of rapid-cycling in women. In addition to hypothyroidism and gonadal steroid effects, a third risk factor exists that may predispose women to rapid-cycling. It is well established that antidepressant medication can precipitate manic episodes. At face value this would seem to suggest an avoidance of antidepressants, but the picture is less clear....