A recent trial of the drug Tamoxifen with patients who were experiencing mania, or who were in a mixed state that included mania as a component, significantly reduced the symptoms of mania in nearly half the sample.
Tamoxifen is normally associated with the treatment of breast cancer but its action is to inhibit a group of enzymes known as protein kinase C. This has relevance to bipolar disorder as abnormal activity by these enzymes is know to affect judgments, problem-solving,...

