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Saturday, July 19, 2008

Paxil and Symbyax

Harvard Health Publications
Copyright 2006 Harvard Health Publications

Question:

I am taking Symbyax for depression. I was on Paxil before, and the new medication was given to me as sample pills. I would like to know what the side effects are. Also, what withdrawal symptoms may occur when taken off it? What is the difference between Paxil and Symbyax?

Answer:

Symbyax is a combination product that contains an atypical antipsychotic drug called olanzapine (also known as Zyprexa) and an antidepressant drug called fluoxetine (also known as Prozac). Symbyax is approved for use in people with depression associated with bipolar disorder.

The side effects of fluoxetine are similar to those of the other selective serotonin reuptake inhibitor (SSRI) antidepressants and include nausea, diarrhea, appetite suppression, insomnia, headache sexual dysfunction and nervousness. Olanzapine can cause a number of side effects. Although olanzapine is less likely to cause problems than the older antipsychotic drugs like Haldol, some people do develop tremor, restlessness and Parkinson's disease-like symptoms. People taking olanzapine may also experience significant weight gain and there is an increased risk of type 2 diabetes.

These side effects can sound rather frightening but they need to be put into perspective. Bipolar disorder can be a serious condition that may have a significant impact on people's lives. Although the side effects of Symbyax can be serious, the drug is of benefit to many people suffering from bipolar disorder.


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Harvard Health Publications Source: from the Harvard Health Publications Family Health Guide, Copyright © 2007 by President and Fellows of Harvard College. All rights reserved.

Used with permission of StayWell.

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