Researchers at the University of Michigan Comprehensive Cancer Center in Ann Arbor have identified a gene linked to the development of an aggressive form of breast cancer.
The gene, FOXP3, has been found to suppress tumor growth. Scientists discovered that when one copy of the FOXP3 gene, located on the X chromosome, is silenced, deleted or mutated, 80 to 90 percent of the samples studied were cancerous and did not express the gene at all.
The researchers also found FOXP3 to repress the protein HER-2, which typically marks a more agressive form of breast cancer. When FOXP3 is normal, it has shown to keep HER-2 levels low. When FOXP3 is mutated or missing, HER-2 levels are likely to rise.
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Best of health,
Published On: July 29, 2007