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Hi: TPBM is short for a molecule of the chemical compound theophylline, 8-[(benzylthio)methyl]-(7CI,8CI). It was the subject of an interesting talk at yesterday's Endocrine Society conference in San Francisco. Apparently, it could be the base for the next generation of drugs that suppress ER-receptive breast cancer by inhibiting estrogen reception. Tamoxifen and aromatase inhibitors, currently being used to treat breast cancer, inhibit estrogen in two different ways; TPBM drugs could provide a third way. This is important, as breast cancer eventually becomes resistant to tamoxifen, and aromatase inhibitors come with lots of unpleasant side effects. Hope this helps you out- - PJH

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