Thank you for the quick reply.  I got the paperwork for the clinical trials yesterday and haven't had time to read it, or to research the Avastin.  My onc said Avastin is already being used with success in advanced stage cancers and the study is investigating whether it might add to the effectiveness of the "standard" carbo/taxo mix for earlier stage HER-2+ cancers as well.    I'll pay attention to the heart implications, especially with the Herceptin already posing an issue there.  I don't have a family history of c/v problems and they'll be doing a MUGA scan before I start but I wouldn't want to add an unnecessary risk with questionable benefits.