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Sunday, February 27, 2011 Sushara asks

Q: What does the "Architecture" classification mean on the biopsy? ie. Infiltrating Well Differentiated Ductal Carcinoma, Grade 1, Nottingham Score 5/9 (Architecture 2, Nuclei 2, Mitosis 1)

The carcinoma measures 6mm in greatest linear dimension on the glass slides and is reported to measure 6mm by imaging. No intraductal component or lymph-vascular invasion is recognized.
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PJ Hamel, Health Guide
2/27/11 10:13am

Sushara, please read our Guide to Understanding Your Pathology Report - you'll find a lot of really helpful information as you try to interpret some of the complicated "medicalese" in the typical pathology report.

 

The Nottingham score you see on your report measures the same thing as the Scharff-Bloom-Richardson score you'll read about in the guide - and I believe "architecture" is the same as "cellular differentiaition" - basically, it refers to the ability of the cancer cells to build breast tissue like normal cells do. Cancer cells that aren’t very aggressive act “normal” enough to do this, and receive a score of 1. Cancer cells that are aggressive and growing quickly lose their ability to build breast tissue; they’re just too wild. They receive a score of 3. So, it looks like you're right in the middle... Good luck with your treatment, and come back again if we can help. PJH

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By Sushara— Last Modified: 02/27/11, First Published: 02/27/11