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Tuesday, August 10, 2010 j, Community Member, asks

Q: what is membrane staining score on my pathology report? I have invasive ductal carcinoma grade2

I just got diagnosed with invasive ductal carcinoma grade 2 & DCIS grade2. I am trying to understand pathology report. It says ER/PR+ 100%,.


HER-2neu score uniform, intense membrane staining of more than 30% of tumor cells, score 3, positive.


Ki67 Proliferlation Index favorable <10%, borderline 10-20%, unfavorable, >20%.


What does that mean?



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Answers (1)
PJ Hamel, Health Guide
8/10/10 6:13am

Hi - Please read our Guide to Understanding your Pathology Report - it'll really help you out with all of this "medicalese." Basically, you have two kinds of cancer: IDC and DCIS, both very common. Your cancer is hormone-receptive (which is a good thing; it means it'll respond to hormone drugs); and it's also HER2-receptive, which means there's another drug you can take, Herceptin. The Ki67 score indicates it's more aggressive rather than less aggressive, so your oncologist will tend to be more aggressive with your treatment. Hope this helps - any further questions, refer to our Guide, or ask your onco to sit down with you and explain, OK? Best of luck - PJH

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By j, Community Member— Last Modified: 12/26/10, First Published: 08/10/10