Marie, although depression isn't a well-documented side effect of tamoxifen, many women experience anything from mild depression to major episodes while on this drug. Your fatigue could very well have its root in depression; please speak to your doctor about some anti-depression medication. Remember, depression can be caused by a chemical imbalance; it's not "all in your head." And in the case of survivors, the emotional challenge of having cancer, combined with a possible chemical shift due to tamoxifen, can bring on depression. So ask about it.

As for the weight loss - most women I know put on weight while taking tamoxifen, so not sure tamoxifen is connected with this... Keep asking your docs for an answer, though; they're there to help you, so don't give up. Good luck - PJH

Your oncologist can't just leave you hanging with this side effect. I think you should ask him/her what to do next. If there's treatment, you need to be referrred to another doctor. If lifestyle changes will help, ask to be referred to a nutritionist or dietitian. We're not doctors here, and can't give this type of medical advice; that's for your oncologist to do.

"Obese" can be a strange term; it's based on body mass index, and if you have a heavy frame, you might be classified as obese even if you don't meet the standards we usually think of as obese. For instance, my brother-in-law is a weight lifter in unbelievable shape - and he's classified as "obese" because of his muscle mass. So don't take that term too much to heart, OK? Find out from your oncologist what your next steps will be, and start taking them. BTW, I gained 15 pounds on tamoxifen; and lost most of it after I stopped taking it (though it took awhile). So there's hope! Good luck - PJH