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Vi, there are lots of things that contribute to weight gain, including a slower metabolism post-menopause. Tough as it is, the answer is often fewer/better calories, more exercise. Also, weight-bearing exercises (e.g., weightlifting) are very good for you, as they help counteract the loss of bone density you'll get from an aromatase inhibitor. Also, if you're having sleep issues, lack of sleep can help pack on the pounds, too. So it may not be the AIs per se making you gain weight - it might be a whole bunch of other factors that have all converged at the same time as taking the AIs. Since AIs have been proven very effective at preventing recurrence, I'd say try to hang in there with them as long as you can... As Sherree mentioned, you probably don't need an endocrinologist. There's no magic solution here, just some tough decisions. Good luck to you. PJH