This will depend on the type of work you do, how flexible your employers are, and the type of chem you are on.  I'm a teacher, and I was on summer vacation during the Adriamycin/Cytoxan part of my chemo.  It made me really fatigued, and I don't think that I could have worked during it.  However, I know other people who worked through AC chemo.  By the fall I was on Taxol, and I did work through that and radiation.  I did not do anything else, just went home and collapsed and let my husband get supper, etc.  People vary widely in their energy level and response to chemo.  If you have employers who can be flexible with your hours, then unless there is some particular problem with the type of work you do being incompatible with chemo, then I say give it a try.  If it turns out to be too much, you can stop.