What can be done to deal with the side effects of AI? I just had a bilateral mastectomy a week ago so I've not started AI treatment yet. Fortunately my nodes were clear so I may not need chemo or radiation. The thought of increasing pain is pretty unappealing. I'll do it because I have to, but I've already been dealing with joint and muscle pain for the last 15 years. My fibromyalgia pain is managed to a tolerable degree with Neurontin, Wellbutrin, Aleve, and Clonodine (for hot flashes). Do these meds help with AI side effects? If not, what does help? I just spent the last year killing myself to lose 75lbs and I read one of the side effects of AI might be weight gain - agh! I gained a lot of those pounds when I was in the BCPT trial of Tamoxifen for 5 years. I also had the hot flashes from hell those 5 years, then right after the study was finished I had to have a hysterectomy so I've been a hot woman for 15 years! Enough already!!! Please advise so I know what to ask the medical oncologist when I see her next week.