Mary, the key here is "physician supervised" - You MUST have both the doctor supervising your diet, and your oncolgist, sign off on whatever the diet entails, including anything you take, like hormones. Considering the hcG diet has been labeled a "scam" by at least some physicians, you might have a hard time getting that signoff. Bottom line: don't take any medication/hormone without checking with your oncologist, who'll let you know if it'll affect Arimidex's effectiveness. Good luck - PJH