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That's a real tough call. since we're not medical professionals.  Though keep in mind that certain chemo drugs can only be used once.  This is something I am figuring out as a 2-peater. My 1st time around with Stage 11a Invasive Ductal Carcinoma, grade 3, her2 negative - I was given an A/C combo every other week for 4 total sessions.  Now 3 years later with a recurrence in my chest wall, I was given 31 sessions of radiation and will follow up with a Taxol based chemo regimen for 4 sessions (likely 1 every other week.)  The docs beleive that my cancer returned caused the Femara failed to keep the estrogen from binding to the one tiny little missed cancer cell that was left behind - so it just grew over the course of 3 years.....even though I had a mastectomy and chemo.  If I had done radiation then, they beleive that it would not have returned as radiation is a localized therapy that kills calls at the source and chemo is a systematic therapy that kills rouge cells wondering the body or that has spread.   If you choose to do A/C & Taxol, I understand that it will potentially mess up your options if the cancer were to ever return, which is something to discuss with your doctor.  Our advice should not replace that of a doctor's - but please consider all options and discuss them thoroughly.  Everyone's cancer, as well as their treatment is different, so you need to do what is best for you.   Good luck! Angi