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Hi - There are very few studies involving men on aromatase inhibitors for breast cancer, simply because breast cancer is so rare in men, and aromatase inhibitors are still a very new treatment. That said, the few cases that have been studied seem to show that men respond to AIs as well as women do. As for Zoladex, it's a testosterone inhibitor, so the side effects would be those involved with low testosterone levels. I suspect these would be challenging for you; tough decision. I wish you luck - PJH

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