Thursday, May 31, 2012
Just Diagnosed with Cancer? Chat with Experts

Sunday, February 01, 2009 Renee Sage asks

Q: The side effects of AC treatment years later

1998-went through 4 cycles of AC and 37 radiation treatments for Breast CA=Aggressive Age 34.  I was told that AC side effect can be weakened heart muscle.  Recent:  Echo shows Ejection Fraction of only 40%.  Also in hospital with PNA. (prompting ECHO)  The MD's suspect the low EF is due to h/o AC. 

 

Q:  Is this possible?

I know I was told that one of the side effects of AC was damage to the heart muscle.  Just need clarification.

 

Q:  Is there anything I can do about it now?

 

Q:  I was told that the PNA was possibly brought on by weakened immune.  Could that be blamed on chemo this many years out?

 

I should also add that 3 years ago I was diagnosed with breast CA again.  It was not mets from 98'.  It was opposite side and not the aggressive CA that I had in 98'.  I chose no Tx despite the options that the oncologist recommended. 

Answer This
Answers (2)
Phyllis Johnson, Health Guide
2/ 1/09 6:40am

Renee, I also had AC chemo in 1998 and was given the same info about possible heart damage.  I recently went through some tests for possible heart concerns and asked about whether my previous chemo could be a factor.  According to my doctors, damage from the chemo would usually show up sooner than ten years, but sometimes it is a long-term side effect.  My doctors also believe that the immune system bounces back after chemo, but my own experience is that I am more likely to catch things than I used to be.  There is probably no way to know now how much of a factor the chemo is in  your current health problems.  I do know other cancer patients who had to stop chemo because their Ejection Fraction dropped who were able to resume it later when they improved.  However, I don't know what they did to get better.  Your situation sounds complicated because you are treating more than one condition.  Are your doctors talking to one another?  You might consider a second opinion about what can be done since yours is a complex case.

Reply
PJ Hamel, Health Guide
2/ 1/09 2:10pm

Renee, sorry, I don't understand a lot of your medical shorthand here. But yes, it's true, Adriamycin can cause heart damage. Is there anything you can do about it - i.e., reverse the damage? That would be a question for a cardiologist, who would look at your situation and develop a treatment plan, if treatment is possible. As for a weakened immune system, my oncologist says that any effects to the immune system from chemo fade pretty quickly, within months, so the AC probably isn't to blame for that. But maybe your weakened immune system was partially responsible for your second bout of cancer? Could be some underlying cause there, something they're not seeing... I'd imagine you're going to be seeing a bunch of docs in the near future. I'd ask about the possible causes for your compromised immunity, OK? Good luck - PJH

Reply
Answer This

Important:
We hope you find this general health information helpful. Please note however, that this Q&A is meant to support not replace the professional medical advice you receive from your doctor. No information in the Answers above is intended to diagnose or treat any condition. The views expressed in the Answers above belong to the individuals who posted them and do not necessarily reflect the views of Remedy Health Media. Remedy Health Media does not review or edit content posted by our community members, but reserves the right to remove any material it deems inappropriate.

Ask a Question

Get answers from our experts and community members.

Btn_ask_question_med
View all questions (6580) >
By Renee Sage— Last Modified: 12/27/10, First Published: 02/01/09