Intraductal Carcinoma In Situ

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Preinvasive cervical carcinoma is referred to as carcinoma in situ, or cervical intraepithelial neoplasia III.

The squamocolumnar junction of the cervix is an area of active squamous cell proliferation. At puberty, due to hormonal changes and possibly due to changes in vaginal acidity, the squamous margin begins to encroach on the single layer of mucus-secreting cells, creating an area of metaplasia (cellular changes) known as the "transformation zone." Over time, varying degrees of atypical...

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