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Doctor Cane, I'm on Norpace CR 200mg twice a day for PVC's......and have been since 1983. Norpace can also affect the liver. So, would it be wise for me to take two (2) drugs (Norpace and Nispan) both which could potentially harm my liver? Niaspan has been advised for me by 3 of my doctors; cardiologist, family doctor, and endocrinologist. And they all arrived at this conclusion independently. I had liver problems back in 2000 prior to when I had exploratory abdominal surgery to determine what was causing my liver to stop functioning. It was learn that my liver bile ducts when practically, if not totally, closed up. They had to put a stent in my bile ducts in order to get it to work again. I had gotten very bad off and was totally gold in color.....became septic and was circling the drain as is said when one is near death. As it turned out thank God, my Gall Bladder was diseased and enlarged and was pressing against the bile ducts causing the problem. Things could have been much worse. So, I always try to learn as much as possible about the drugs I take.