Friday, August 22, 2014
Saturday, May 03, 2008 karenk5109, Community Member, asks

Q: Why can't you eat grapefruit while taking SimVastin prescription? What are symptoms?

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Answers (3)
Allison Bush, Editor
5/ 6/08 3:03pm

Hi, and thank you for your question. Our cholesterol expert, Dr. Kang, actually wrote an entire article on grapfruit juice and cholesterol medication that you can read in full, but I will try and pull out the important parts for quick reference. Also, please be sure to check with your own doctor for specific info related to your health.

 

"Grapefruit contains certain chemical compounds called polyphenolics that inhibit the metabolism or break down of some medications, statins being one of the most notorious.  Statins are highly effective and one of the most commonly prescribed cholesterol lowering medicines.  This class of medication inhibits a liver enzyme and can lower LDL by ~50% and raise HDL.  Drugs in the statin class include lovastatin, pravastatin, simvastatin, fluvastatin, atorvastatin, and rosuvastatin.  Although generally safe, statins have the potential to cause serious side effects such as muscle injury and liver damage.

 

Enzymes called cytochromes metabolize many drugs such as statins.  Most of these enzymes are concentrated in the liver, but some of them are found else where in the body such as in the gut.  One cytochrome in particular called CYP3A4 is quite predominant in the small intestine and significantly participates in the breakdown of statins.  Grapefruit can inhibit the activity of this intestinal cytochrome thereby increasing the level of statins in the blood stream.  More drug can therefore lead to a higher risk of side effects.  As little as 8 oz. of grapefruit juice can have a significant effect on drug levels.  And, the effect of eating a single serving of grapefruit may last as long as 24 hours.

 

Fortunately, all is not lost for my mother-in-law.  Mangos, oranges, and orange juice do not effect statin levels.  Although other citrus fruits such as limes and Seville oranges (sour oranges) do contain some similar chemical compounds to grapefruits, there have been no significant reports of them leading to harm with statins.  Also, not all statins are subject to the effects of grapefruit.  Pravastatin undergoes little breakdown by the intestinal cytochrome and is safe to take with grapefruit juice.  Whether these alternatives will be satisfactory to my mother-in-law waits to be seen.  But it saddens me to see two kindred spirits separated by one cholesterol medicine."

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jwalmsley, Community Member
6/27/08 9:26am

why does the prescription label for simvastatin say not to eat grapefruit while taking this medication?

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JUDY, Community Member
12/26/08 5:14pm

WHAT WILL HAPPEN IF I EAT A GRAPEFRUIT WHEN I TAKE SIMVASTIM FOR MY CHOLESTROL

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Capt. Dave, Community Member
1/28/11 11:09am

Your genetallia becomes over  senstive and one could find themselves engaged in nontraditional sex acts, in public.

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By karenk5109, Community Member— Last Modified: 05/20/14, First Published: 05/03/08