Generic Name: NIACIN EXTENDED-RELEASE/SIMVASTATIN - ORAL Pronounced: (NYE-a-sin/SIM-va-STAT-in) Niacin-simvastatin Oral Precautions
Before taking this product, tell your doctor or pharmacist
if you are allergic to niacin or simvastatin; or if you have any other
allergies. This product may contain inactive ingredients, which can cause
allergic reactions or other problems. Talk to your pharmacist for more
Before using this medication, tell your doctor or
pharmacist your medical history, especially of:
Before having surgery, tell your doctor or dentist about
all the products you use (including prescription drugs, nonprescription drugs,
and herbal products).
This drug may make you dizzy. Do not drive, use machinery,
or do any activity that requires alertness until you are sure you can perform
My mother-in-law has been visiting with us for the past few weeks. She remarked one day while peeling a mango how she felt as if she had a kindred spirit with citrus fruit, but was quick to also mention how disappointed she was to learn that she is no longer able to eat grapefruit. When asked why, she simply replied, “I’m on cholesterol medication .”
That wonderful, thick skinned, tangy yet sweet fruit that is also known as the forbidden fruit of Barbados and grows in clusters like grapes is well known for its interactions with multiple medications. Grapefruit contains certain chemical compounds called polyphenolics that inhibit the metabolism or break down of some medications, statins being one of the most notorious. Statins are highly effective and one of the most commonly prescribed cholesterol lowering medicines. This class of medication inhibits a liver enzyme and can lower LDL by ~50% and raise HDL . Drugs in the statin class in...
The makers of Vytorin®, Merck/Schering-Plough Pharmaceuticals, recently issued a controversial press release about the Enhance Study that compared the effects of Vytorin® (a combination of simvastatin and ezetimibe, brand name Zetia®) vs. just simvastatin. No substantial difference was observed with the addition of Zetia®, perhaps even a negative effect. The news has triggered a media frenzy. The New York Times headlined the story, " Drug Has No Benefit in Trial ." "Drug doesn't slow artery clogs," declares the Washington Post . A medical marketing website declared "Vytorin study's a stinker." This has been followed by some journalists and scientists calling the entire lipid hypothesis , the notion that high cholesterol forms atherosclerotic plaque and heart disease, into doubt. "New Questions on Treating Cholesterol" ( http://www.nytimes.com/2008/01/17/business/17drug.html?ex=1358312400&en=11b68f069a83f57c&a...
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