"This is a pretty clear failure. Physicians should now stop using ezetimibe or Vytorin except as a last resort." - Dr. Steven Nissen (Cleveland Clinic, OH) "Dr. Nissen's suggestion about a moratorium on ezitimibe is rather alarmist, given that this was just an imaging study, and an imaging study should not change clinical practice." - Dr. Robert Harrington (Duke Clinical Research Institute, Durham, NC) These 2 quotes pertain to the January 14th release of the ENHANCE study, a trial that evaluated the effects of ezetimibe + simvastatin (aka Vytorin ) on preventing neck artery thickness. As you can tell, the announcement by the manufacturers Merck and Schering-Plough was disappointingly negative and has generated significant controversy. Talk about timing. I just wrote my last article in early January on ezetimibe and how the liver safety of this medication when used in combination with a statin was called into question. One reaso...
Generic Name: SITAGLIPTIN/SIMVASTATIN - ORAL Pronounced: (SYE-ta-GLIP-tin/SIM-va-STAT-in) sitagliptin-simvastatin Oral Precautions
Before taking this product, tell your doctor or pharmacist
if you are allergic to sitagliptin or simvastatin; or if you have any other
allergies. This product may contain inactive ingredients, which can cause
allergic reactions or other problems. Talk to your pharmacist for more
Before using this medication, tell your doctor or
pharmacist your medical history, especially of:
disease of the pancreas (pancreatitis)
You may experience blurred vision, dizziness, or
drowsiness due to extremely low or high blood sugar levels. Do not drive, use
machinery, or do any activity that requires alertness or clear vision until you
are sure you can perform such activities safely.
Before having surgery, tell your doctor or dentist about
all the p...
My mother-in-law has been visiting with us for the past few weeks. She remarked one day while peeling a mango how she felt as if she had a kindred spirit with citrus fruit, but was quick to also mention how disappointed she was to learn that she is no longer able to eat grapefruit. When asked why, she simply replied, “I’m on cholesterol medication .”
That wonderful, thick skinned, tangy yet sweet fruit that is also known as the forbidden fruit of Barbados and grows in clusters like grapes is well known for its interactions with multiple medications. Grapefruit contains certain chemical compounds called polyphenolics that inhibit the metabolism or break down of some medications, statins being one of the most notorious. Statins are highly effective and one of the most commonly prescribed cholesterol lowering medicines. This class of medication inhibits a liver enzyme and can lower LDL by ~50% and raise HDL . Drugs in the statin class in...
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