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Hi Dionne, All medications affect people differently. Zetia is more likely to cause diarrhea then constipation, however, it doesn't mean that constipation isn't possible with this medication. You may find this information helpful: http://www.healthcentral.com/cholesterol/find-drug-113048-73.html. If constipation persists, I would recommend contacting your doctor. Thanks for your question! Jill
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