• SkyeFlion SkyeFlion
    September 15, 2008
    Why is it recommended that you take Simvastatin in the evening?
    SkyeFlion SkyeFlion
    September 15, 2008

FROM OUR EXPERTS

  • Martin Cane, M.D.
    Health Pro
    September 15, 2008
    Martin Cane, M.D.
    Health Pro
    September 15, 2008

    SkyeFllion,

     

    Thanks for your question.  Simvastatin is the generic for Zocor, one of the stronger statin medications available for the treatment of elevated cholestrol levels.  Most statin medications are recommended to be taken in the evening, though Crestor (another statin) can be taken at any time of day. 

     

    Apparently, the drug half-life (how long it lasts in your body) is a factor in determining this.  One study monitored LDL (low density lipoprotein levels of Cholesterol) following doses of statin medications.  Lower levels of LDL were observed when these medications were taken in the evening rather than the morning. 

     

    Please review our website for tips and suggestions for keeping your cholesterol under control (in addition to your medication).

     

    Best wishes. 

     

    Martin Cane, M.D.

    • ES
      ES
      September 24, 2009
      ES
      ES
      September 24, 2009

      I work 9 PM to 7 AM for 7 nights in a row and then off 7 where I turn around and sleep during the night. So, when should I take Zocor? Thanks

       

       

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    • shalili
      March 23, 2010
      shalili
      March 23, 2010

      The answer is that,  more of the body's cholesterol is formed during the night, so taking the statin in the evening allows it to work all night on the new cholesterol being formed9in the liver), thus helping to maintain/lower your cholesterol levels.

      half life plys a role too, but the main ting is the production/ removal of cholesterol from the night.

      READ MORE
    • WisdomLady
      May 08, 2010
      WisdomLady
      May 08, 2010

      I am also interested in this topic.

      READ MORE

FROM OUR COMMUNITY

  • BOBBI MOREIN September 18, 2008
    BOBBI MOREIN
    September 18, 2008

    IT IS MORE EFFECTIVE AFTER FOOD HAS BEEN CONSUMED DURING THE DAY

    READ MORE
  • Denise September 18, 2008
    Denise
    September 18, 2008

    it is supposed to be effective

    READ MORE
  • William Schaffer September 18, 2008
    William Schaffer
    September 18, 2008

    Cholesterol and LDL synthesis is greatest during the fasting period early in the morning.  This coincides with the greatest activity is simnvistatin in the body since the half-life of simvistatin is ~5 hours.  If taken at any other time of the day, the concentration of simvistatin would be lower during the time of high cholesterol synthesis.

    READ MORE
    • JAN
      JAN
      August 10, 2012
      JAN
      JAN
      August 10, 2012

      well now I know why I might comply with the doctors suggestion!!

       

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  • sherry vigeant September 18, 2008
    sherry vigeant
    September 18, 2008

    Why do we have to take simvastatin in the evening? My doctor did not tell me this

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  • grantdf September 18, 2008
    grantdf
    September 18, 2008

    It works better at night when the stomach isn't full and the body is resting.

    READ MORE
  • SkyeFlion September 18, 2008
    SkyeFlion
    September 18, 2008

    This is ~SkyeFlion~

     

    Thanks for all your answers, some of which bring me to another question: 

    I generally take all of my pills at about 7:00 AM.  I start my workday day with a SlimFast at about 8:15 AM.  I then drink about a half gallon of water before my 1:00 PM lunch break.  This means my stomach is empty when I take the Simvastatin and pretty much stays that way through the morning except for the above.  I hope you can tell me this will work as well as taking it in the evening.  I do not have any other pill to take in the evening and am worried I will be constantly forgetting this if I have to switch to the evening for this one medication.

    READ MORE
    • momchangdhername
      May 25, 2010
      momchangdhername
      May 25, 2010

      surely in todays technological world you have a cell phone that has a reminder setting?? this is what my husband and I do to remember to take our morning and evening medication. after a few weeks a habit will be formed and you will be turning off that reminder before it even goes off.

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    • Sheila Tolley
      March 06, 2014
      Sheila Tolley
      March 06, 2014

      If you have no children, place the pill on your alarm clock. When you set the alarm, take the pill.

      READ MORE
    • Nrs4u
      April 24, 2014
      Nrs4u
      April 24, 2014

      Some (but not all) statin medications must be taken in the evening. The liver produces the most cholesterol in the middle of the night (in the early morning hours). Therefore, it is best to take short-acting statins in the evening because taking them early in the day would decrease their effectiveness. Just an FYI for you!

      READ MORE
  • Bill Duggan September 18, 2008
    Bill Duggan
    September 18, 2008

    I don't know

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  • bill September 18, 2008
    bill
    September 18, 2008

    full stomach

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  • mwash September 18, 2008
    mwash
    September 18, 2008

    It was recommended that I take Simvastatin in the evening because this pill works on the liver.  It works better at bedtime when taken after or during dinner.

    READ MORE
  • Fuentesrob September 18, 2008
    Fuentesrob
    September 18, 2008

    Cholesterol is absorbed in the evening when you sleep.

    READ MORE
  • lorene September 18, 2008
    lorene
    September 18, 2008

    I belive other than sometimes make you alittle sick,it also has been known to make you dizzy and sleepy.So as you sleep you won't notice these.

    READ MORE
  • Margaret September 18, 2008
    Margaret
    September 18, 2008

    So it has time to work through your system.

    READ MORE
  • Rosita September 18, 2008
    Rosita
    September 18, 2008

    because you eat during the day, but not at night when you a sleep

    READ MORE
  • Ramona Hopkins September 18, 2008
    Ramona Hopkins
    September 18, 2008

    It works better after you have eaten your last meal for the day. The food is breaking down so it is easier for the medicine to work.

    READ MORE
  • Mern November 20, 2008
    Mern
    November 20, 2008

    My Husband's Cardiologist advised him to take his Zocor in the evening after his meal.  This way the drug stays in your system longer due to a full stomach.  Also it lessens the possible side affect of nausea.

    READ MORE
  • dawn September 26, 2008
    dawn
    September 26, 2008

    i do not know

    READ MORE
  • JIMMIED September 19, 2008
    JIMMIED
    September 19, 2008
    I GIVE UP, TELL ME~ READ MORE
  • robert12 September 19, 2008
    robert12
    September 19, 2008

    The metabolism of cholesterol in our body is not the same at night, it must be more active  at this time ? 

    READ MORE
  • Sherry Kelley September 19, 2008
    Sherry Kelley
    September 19, 2008

    Becuase it raises your blood pressure?

    READ MORE
  • terri September 19, 2008
    terri
    September 19, 2008

    works better

    READ MORE
  • JIMMIED September 19, 2008
    JIMMIED
    September 19, 2008
    So you won't take it in the morning and ruin your day? READ MORE
  • blondie February 22, 2010
    blondie
    February 22, 2010

    nineteen days after starting simvistatin my ldl's went from 154 to 87 and my triglycerides from 169 to 66. is this reasonable progress?

    READ MORE
  • blondie February 22, 2010
    blondie
    February 22, 2010

    would it be reasonable for zocor to reduce my ldl from 154 to 87 and triglycerides from 169 to 66 by 19 days after starting simvistatin?

    READ MORE
  • nuttypiglet October 13, 2011
    nuttypiglet
    October 13, 2011

    The Liver creates new lipids and fills them with fat for distribution much more when you sleep than when you are awake. This is why, when you read the drug companies leaflet, it says AT NIGHT. Some statins don't require night time consumption because they work in a slightly different way.

    Just to add, it makes no difference whatsoever if you take them on a full stomach or not. This medication is aimed at the Liver, not the digestive system. Medications such as Ezetimibe will affect the gut, by reducing the amount of fat absorbed.

    Around 20-25% of fat in the Liver comes from the food we eat, the rest is made by the Liver. This is why people with Familial Hypercholesterolemia for example have cholesterol levels through the roof even if they live on salads. 

    READ MORE
  • Catherine Cleveland October 30, 2010
    Catherine Cleveland
    October 30, 2010

    Can simvastatin be taken with food or needs to be taken with a empty stomach.

     

    READ MORE
  • ash1001 January 24, 2013
    ash1001
    January 24, 2013

    Well now I am really confused, I asked the pharmacist and he suggested |I take it in the evening, which I have tried this week, but when i take my blood pressure medication in the morning, I feel rather 'yuk' and lifeless for a couple of hours. There are also ''personal' side effects in the morning.

    So think its a trip back to the docs for me, or maybe just revert to taking Simvastatin just after my evening meal.

    READ MORE
  • ash1001 January 24, 2013
    ash1001
    January 24, 2013

    Well now I am really confused, I asked the pharmacist and he suggested |I take it in the evening, which I have tried this week, but when i take my blood pressure medication in the morning, I feel rather 'yuk' and lifeless for a couple of hours. There are also ''personal' side effects in the morning.

    So think its a trip back to the docs for me, or maybe just revert to taking Simvastatin just after my evening meal.

    READ MORE
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