Why is it recommended that you take Simvastatin in the evening?

SkyeFllion,

Thanks for your question.  Simvastatin is the generic for Zocor, one of the stronger statin medications available for the treatment of elevated cholestrol levels.  Most statin medications are recommended to be taken in the evening, though Crestor (another statin) can be taken at any time of day. 

Apparently, the drug half-life (how long it lasts in your body) is a factor in determining this.  One study monitored LDL (low density lipoprotein levels of Cholesterol) following doses of statin medications.  Lower levels of LDL were observed when these medications were taken in the evening rather than the morning. 

Please review our website for tips and suggestions for keeping your cholesterol under control (in addition to your medication).

Best wishes. 

Martin Cane, M.D.

I don't know

It works better after you have eaten your last meal for the day. The food is breaking down so it is easier for the medicine to work.

IT IS MORE EFFECTIVE AFTER FOOD HAS BEEN CONSUMED DURING THE DAY

Why do we have to take simvastatin in the evening? My doctor did not tell me this

full stomach

It works better at night when the stomach isn't full and the body is resting.

It was recommended that I take Simvastatin in the evening because this pill works on the liver.  It works better at bedtime when taken after or during dinner.

Cholesterol and LDL synthesis is greatest during the fasting period early in the morning.  This coincides with the greatest activity is simnvistatin in the body since the half-life of simvistatin is ~5 hours.  If taken at any other time of the day, the concentration of simvistatin would be lower during the time of high cholesterol synthesis.

it is supposed to be effective

because you eat during the day, but not at night when you a sleep

This is ~SkyeFlion~

Thanks for all your answers, some of which bring me to another question: 

I generally take all of my pills at about 7:00 AM.  I start my workday day with a SlimFast at about 8:15 AM.  I then drink about a half gallon of water before my 1:00 PM lunch break.  This means my stomach is empty when I take the Simvastatin and pretty much stays that way through the morning except for the above.  I hope you can tell me this will work as well as taking it in the evening.  I do not have any other pill to take in the evening and am worried I will be constantly forgetting this if I have to switch to the evening for this one medication.

So it has time to work through your system.

I belive other than sometimes make you alittle sick,it also has been known to make you dizzy and sleepy.So as you sleep you won't notice these.

Cholesterol is absorbed in the evening when you sleep.

works better

Becuase it raises your blood pressure?

The metabolism of cholesterol in our body is not the same at night, it must be more active  at this time ? 

i do not know

My Husband's Cardiologist advised him to take his Zocor in the evening after his meal.  This way the drug stays in your system longer due to a full stomach.  Also it lessens the possible side affect of nausea.