Tuesday, October 21, 2014
Monday, September 15, 2008 SkyeFlion, Community Member, asks

Q: Why is it recommended that you take Simvastatin in the evening?

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Answers (28)
Martin Cane, M.D., Health Pro
9/15/08 11:56am



Thanks for your question.  Simvastatin is the generic for Zocor, one of the stronger statin medications available for the treatment of elevated cholestrol levels.  Most statin medications are recommended to be taken in the evening, though Crestor (another statin) can be taken at any time of day. 


Apparently, the drug half-life (how long it lasts in your body) is a factor in determining this.  One study monitored LDL (low density lipoprotein levels of Cholesterol) following doses of statin medications.  Lower levels of LDL were observed when these medications were taken in the evening rather than the morning. 


Please review our website for tips and suggestions for keeping your cholesterol under control (in addition to your medication).


Best wishes. 


Martin Cane, M.D.

ES, Community Member
9/24/09 7:37am

I work 9 PM to 7 AM for 7 nights in a row and then off 7 where I turn around and sleep during the night. So, when should I take Zocor? Thanks



shalili, Community Member
3/23/10 8:24pm

The answer is that,  more of the body's cholesterol is formed during the night, so taking the statin in the evening allows it to work all night on the new cholesterol being formed9in the liver), thus helping to maintain/lower your cholesterol levels.

half life plys a role too, but the main ting is the production/ removal of cholesterol from the night.

WisdomLady, Community Member
5/ 8/10 5:19pm

I am also interested in this topic.

Bill Duggan, Community Member
9/18/08 10:56am

I don't know

Ramona Hopkins, Community Member
9/18/08 11:26am

It works better after you have eaten your last meal for the day. The food is breaking down so it is easier for the medicine to work.

BOBBI MOREIN, Community Member
9/18/08 11:27am


sherry vigeant, Community Member
9/18/08 11:41am

Why do we have to take simvastatin in the evening? My doctor did not tell me this

bill, Community Member
9/18/08 11:50am

full stomach

grantdf, Community Member
9/18/08 12:09pm

It works better at night when the stomach isn't full and the body is resting.

mwash, Community Member
9/18/08 12:23pm

It was recommended that I take Simvastatin in the evening because this pill works on the liver.  It works better at bedtime when taken after or during dinner.

William Schaffer, Community Member
9/18/08 2:19pm

Cholesterol and LDL synthesis is greatest during the fasting period early in the morning.  This coincides with the greatest activity is simnvistatin in the body since the half-life of simvistatin is ~5 hours.  If taken at any other time of the day, the concentration of simvistatin would be lower during the time of high cholesterol synthesis.

JAN, Community Member
8/10/12 10:43am

well now I know why I might comply with the doctors suggestion!!


Denise, Community Member
9/18/08 3:57pm

it is supposed to be effective

Rosita, Community Member
9/18/08 4:12pm

because you eat during the day, but not at night when you a sleep

SkyeFlion, Community Member
9/18/08 4:14pm

This is ~SkyeFlion~


Thanks for all your answers, some of which bring me to another question: 

I generally take all of my pills at about 7:00 AM.  I start my workday day with a SlimFast at about 8:15 AM.  I then drink about a half gallon of water before my 1:00 PM lunch break.  This means my stomach is empty when I take the Simvastatin and pretty much stays that way through the morning except for the above.  I hope you can tell me this will work as well as taking it in the evening.  I do not have any other pill to take in the evening and am worried I will be constantly forgetting this if I have to switch to the evening for this one medication.

momchangdhername, Community Member
5/25/10 8:41am

surely in todays technological world you have a cell phone that has a reminder setting?? this is what my husband and I do to remember to take our morning and evening medication. after a few weeks a habit will be formed and you will be turning off that reminder before it even goes off.

Sheila Tolley, Community Member
3/ 6/14 9:50am

If you have no children, place the pill on your alarm clock. When you set the alarm, take the pill.

Nrs4u, Community Member
4/24/14 7:12am

Some (but not all) statin medications must be taken in the evening. The liver produces the most cholesterol in the middle of the night (in the early morning hours). Therefore, it is best to take short-acting statins in the evening because taking them early in the day would decrease their effectiveness. Just an FYI for you!

Margaret, Community Member
9/18/08 5:48pm

So it has time to work through your system.

lorene, Community Member
9/18/08 7:18pm

I belive other than sometimes make you alittle sick,it also has been known to make you dizzy and sleepy.So as you sleep you won't notice these.

Fuentesrob, Community Member
9/18/08 10:38pm

Cholesterol is absorbed in the evening when you sleep.

terri, Community Member
9/19/08 6:49am

works better

Sherry Kelley, Community Member
9/19/08 8:33am

Becuase it raises your blood pressure?

robert12, Community Member
9/19/08 9:42am

The metabolism of cholesterol in our body is not the same at night, it must be more active  at this time ? 

JIMMIED, Community Member
9/19/08 1:58pm
JIMMIED, Community Member
9/19/08 1:59pm
So you won't take it in the morning and ruin your day? Reply
dawn, Community Member
9/26/08 7:17pm

i do not know

Mern, Community Member
11/20/08 11:06am

My Husband's Cardiologist advised him to take his Zocor in the evening after his meal.  This way the drug stays in your system longer due to a full stomach.  Also it lessens the possible side affect of nausea.

blondie, Community Member
2/22/10 3:58pm

would it be reasonable for zocor to reduce my ldl from 154 to 87 and triglycerides from 169 to 66 by 19 days after starting simvistatin?

blondie, Community Member
2/22/10 4:06pm

nineteen days after starting simvistatin my ldl's went from 154 to 87 and my triglycerides from 169 to 66. is this reasonable progress?

Catherine Cleveland, Community Member
10/30/10 9:03pm

Can simvastatin be taken with food or needs to be taken with a empty stomach.


nuttypiglet, Community Member
10/13/11 9:37pm

The Liver creates new lipids and fills them with fat for distribution much more when you sleep than when you are awake. This is why, when you read the drug companies leaflet, it says AT NIGHT. Some statins don't require night time consumption because they work in a slightly different way.

Just to add, it makes no difference whatsoever if you take them on a full stomach or not. This medication is aimed at the Liver, not the digestive system. Medications such as Ezetimibe will affect the gut, by reducing the amount of fat absorbed.

Around 20-25% of fat in the Liver comes from the food we eat, the rest is made by the Liver. This is why people with Familial Hypercholesterolemia for example have cholesterol levels through the roof even if they live on salads. 

ash1001, Community Member
1/24/13 7:06am

Well now I am really confused, I asked the pharmacist and he suggested |I take it in the evening, which I have tried this week, but when i take my blood pressure medication in the morning, I feel rather 'yuk' and lifeless for a couple of hours. There are also ''personal' side effects in the morning.

So think its a trip back to the docs for me, or maybe just revert to taking Simvastatin just after my evening meal.

ash1001, Community Member
1/24/13 7:08am

Well now I am really confused, I asked the pharmacist and he suggested |I take it in the evening, which I have tried this week, but when i take my blood pressure medication in the morning, I feel rather 'yuk' and lifeless for a couple of hours. There are also ''personal' side effects in the morning.

So think its a trip back to the docs for me, or maybe just revert to taking Simvastatin just after my evening meal.

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By SkyeFlion, Community Member— Last Modified: 04/24/14, First Published: 09/15/08