Thursday, October 23, 2014
Monday, October 20, 2008 Fred, Community Member, asks

Q: Why should Zocor be taken in the evenings instead of mornings?

Answer This
Answers (9)
Martin Cane, M.D., Health Pro
10/21/08 8:10pm



Thanks for your question.  Simvastatin is the generic for Zocor, one of the stronger statin medications available for the treatment of elevated cholestrol levels.  Most statin medications are recommended to be taken in the evening, though Crestor (another statin) can be taken at any time of day. 


The drug half-life (how long it lasts in your body) is a factor in determining the best time for taking the drug, and the half life of zocor is five hours.  This coincides with the time of greatest Cholesterol and LDL production by the liver in a fasting state which is early in the morning.  One study monitored LDL (low density lipoprotein levels of Cholesterol) following doses of statin medications.  Lower levels of LDL were observed when these medications were taken in the evening rather than the morning. 


Please review our website for tips and suggestions for keeping your cholesterol under control (in addition to your medication).


I hope this has been helpful.


Martin Cane, M.D.



Phyllis, Community Member
10/23/08 10:55am

because your body system slows down at nigh, it works better.

Karen, Community Member
10/23/08 12:06pm

The liver produces cholesterol at night while you are resting

topseabug, Community Member
10/23/08 7:39pm

The action of Zocor works best when the body is at rest

sue, Community Member
10/24/08 8:18am

I have no clue but would like to know as nobody has ever told me that

Doris Emery, Community Member
10/24/08 11:32am

so it would work all night

Doris Emery, Community Member
10/24/08 11:34am

So it would work during the night.

Jeanne, Community Member
10/24/08 7:58pm

I don't know why.  I thought you were going to tell me!!

Barbara, Community Member
3/29/11 9:42am

Why can't I take Zocor in the mornings instead of at night?

Answer This

We hope you find this general health information helpful. Please note however, that this Q&A is meant to support not replace the professional medical advice you receive from your doctor. No information in the Answers above is intended to diagnose or treat any condition. The views expressed in the Answers above belong to the individuals who posted them and do not necessarily reflect the views of Remedy Health Media. Remedy Health Media does not review or edit content posted by our community members, but reserves the right to remove any material it deems inappropriate.

By Fred, Community Member— Last Modified: 06/25/12, First Published: 10/20/08