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KHOSROW,   In thinking about your question and my answer, I realized that I mixed up Gemfibrozil and Niaspan.  Gemfibrozil (generic for lopid) is a lipid lowering drug that is most commonly used for triglycerides.  Like the statins, it can also cause muscle pain and damage, as well as affect the liver function tests.  When combined with statins there is a greater risk for an adverse reaction to muscles.   As I stated in my previous response, the timing of the medication will not alter the risk for developing a reaction.  "Together" refers to treatment with both medications.   Martin Cane, M.D.