will taking pravastatin in comb with hp meds drop bp substantially

Thanks Mike for your question.  The only way to get a professional medical opinion is to speak with your doctor regarding your concerns.

In the meantime, you might want to look at our sister site,

HighBloodPressureConnection.com

for more information on HBP.  As well, you might want to refer to the information on Pravachol/Pravastatin:

Pravastatin is an enzyme blocker (HMG-CoA reductase inhibitor), also known as a "statin". It is used in adults and children (8 years of age and older), along with a proper diet, to help lower cholesterol and fats (triglycerides) in the blood. In general, this drug is prescribed after non-drug treatment options have not been fully successful at lowering cholesterol (e.g., diet change, increase in exercise, weight loss if overweight). Reducing cholesterol and triglycerides help prevent strokes and heart attacks.

Specifically the details on drug interactions.

Hope this helps, all the best, sue