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The answer is yes, in my opinion.   Statin drugs (such as Zocor, Lipitor, Lovastatin, Pravachol, Mevacor, and Lescol) may cause cramps and other forms of myopathy because they block cholesterol production in the body by inhibiting the enzyme called HMG-CoA reductase. (Please see the "mevalonate pathway" for details.) Unfortunately, the antioxidant CoQ10 is also synthesized from another HMG-CoA reductase pathway.  Therefore, statin drugs also inhibit CoQ10 (Coenzyme Q10) synthesis. Low levels of CoQ10 could predispose the patients to cramps, including cramping in the heart (heart attack).  Thus, coQ10 is often prescribed or recommended to prevent the cramping.  Some statin drugs now come with coQ10, but I don't know which ones.   Please note that the same arguments apply to red yeast rice, a natural supplement used to lower cholesterol.  It has a natural statin that is a mirror image of one of the prescription statin drugs.  Like the statins, it too can deplete coQ10 so it is often sold with the addition of coQ10.   At the end of the day, I believe that schlerotic deposits in the heart arteries cannot be explained with high levels of cholesterol alone.  You see, cholesterol acts like a glue on sites that are damaged, such as on micro cracks in blood vessels.  Cholesterol levels go up when there is stress (I supposed to suppress a loss of blood in a fight.)  The arteries near the heart can exhibit the highest number of micro cracks because of the huge pressure differentials they are exposed to.  If one is prone to bruising, bleeding gums, and other symptoms of weakened arteries, then it is likely that the heart arteries are clogged.  Scurvy (a Vitamin C deficiency) is a prime example.  Patients with scurvy are prone to bruising, bleeding of the gums, and heart attacks.   So if one is cramping (and there are many causes), it would be worthwhile to ask the doctor to check for mineral levels and all other possible causes with a blood test.    As a note, statin drugs are often prescribed with diuretics that reduce high blood pressure.  Diuretics can deplete minerals and cause cramping.  It's always good to understand the cause of the high blood pressure to take the right action.