I have taken statins for my cholesterol for years and they have worked very well to lower my ldl. However, my CPK has also been elevated at times and I have had to go off the medicine until it drops. My doctor just took me off the statins again because my CPK was 646. I had only been back on them for three months. I have also had issues with muscle weakness/cramping. First, how bad is a 646 CPK? Second, how can I manage my cholesterol without a statin?