My mother-in-law has been visiting with us for the past few weeks. She remarked one day while peeling a mango how she felt as if she had a kindred spirit with citrus fruit, but was quick to also mention how disappointed she was to learn that she is no longer able to eat grapefruit. When asked why, she simply replied, “I’m on cholesterol medication .”
That wonderful, thick skinned, tangy yet sweet fruit that is also known as the forbidden fruit of Barbados and grows in clusters like grapes is well known for its interactions with multiple medications. Grapefruit contains certain chemical compounds called polyphenolics that inhibit the metabolism or break down of some medications, statins being one of the most notorious. Statins are highly effective and one of the most commonly prescribed cholesterol lowering medicines. This class of medication inhibits a liver enzyme and can lower LDL by ~50% and raise HDL . Drugs in the statin class in...
Lisa Nelson RD #8: Please clear up the confusion about grapefruit and medication! Is it safe for individuals taking medication for heart disease, such as Lipitor, to eat grapefruit or drink grapefruit juice? When is grapefruit not allowed?
Dr. Shelby-Lane: I am including information that may help answer your question about grapefruit and a variety of nutritionals that affect statin drugs for the lowering of cholesterol.
Zocor (Simvastatin), for example, is a Statin drug, used to lower high cholesterol levels, and also known as HMG-CoA reductase inhibitor. Zocor may affect the absorption or utilization of vitamins E and coenzyme Q10. Tests showed the average concentration of coenzyme Q10 in blood plasma decreased by approximately 50% after statins were used for 30 days. Supplementation is considered beneficial.
Grapefruit and grapefruit juice may increase the effects of HMG-CoA reductase inhibitors and should not be consumed at the same time. It i...
I try to make sure that Dad and I eat a healthy diet. Lots of produce, chicken and seafood, a nightly Scotch and water, and the occasional treat of chocolate. You would think that would be perfect, but there may be some issues with what I’m feeding him. Why? Because he’s taking about a dozen medications and it’s possible that the foods he eats can interact with his prescriptions.
A San Antonio Express-News story piqued my interest by warning that certain citrus juices can have dangerous interactions with certain medications. They pointed to a study on the effect of alcohol on the blood pressure medicine felodipine conducted by Canadian researcher David Bailey two decades ago. Dr. Bailey used grapefruit juice to mask the taste of alcohol so that he could conduct a “blind” study. He found that as the study progressed the levels of felodipine were much higher than expected in the group that was drinking the grapefruit/alcohol concoction.
You should knowAnswers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Content posted by community members does not necessarily reflect the views of Remedy Health Media, which also reserves the right to remove material deemed inappropriate.