FROM OUR EXPERTS
Generic Name: EZETIMIBE/SIMVASTATIN - ORAL Pronounced: (e-ZET-i-mibe/SIM-va-STAT-in) Ezetimibe-simvastatin Oral Precautions
Before taking this product, tell your doctor or pharmacist
if you are allergic to ezetimibe or simvastatin; or if you have any other
allergies. This product may contain inactive ingredients, which can cause
allergic reactions or other problems. Talk to your pharmacist for more
Before using this medication, tell your doctor or
pharmacist your medical history, especially of:
Before having surgery, tell your doctor or dentist about
all the products you use (including prescription drugs, nonprescription drugs,
and herbal products).
Limit alcoholic beverages. Daily use of alcohol may
increase your risk for liver problems, especially when combined with this
product. Ask your doctor or pharmacist for more information.
Older adults may be mor...
"This is a pretty clear failure. Physicians should now stop using ezetimibe or Vytorin except as a last resort." - Dr. Steven Nissen (Cleveland Clinic, OH) "Dr. Nissen's suggestion about a moratorium on ezitimibe is rather alarmist, given that this was just an imaging study, and an imaging study should not change clinical practice." - Dr. Robert Harrington (Duke Clinical Research Institute, Durham, NC) These 2 quotes pertain to the January 14th release of the ENHANCE study, a trial that evaluated the effects of ezetimibe + simvastatin (aka Vytorin ) on preventing neck artery thickness. As you can tell, the announcement by the manufacturers Merck and Schering-Plough was disappointingly negative and has generated significant controversy. Talk about timing. I just wrote my last article in early January on ezetimibe and how the liver safety of this medication when used in combination with a statin was called into question. One reaso...
A reader recently asked if eating a significant amount of fiber can diminish the effect of Lipitor (atorvastatin) in reducing cholesterol levels. I am not aware of any negative effect of fiber on the absorption or the effects of the statins on lowering cholesterol. Statins including Lipitor can cause gastrointestinal side effects such as diarrhea and interestingly, constipation as well. The mechanism is not completely understood. What I am quite aware of is the overall positive effects of fiber in improving cholesterol levels including evidence to support that fiber can enhance a statin’s effectiveness. Fiber can improve cholesterol levels in several ways. One often overlooked benefit of eating fiber is that it can easily act as a substitute for a potential damaging food . For example, we know that we should minimize the intake of trans and saturated fats . But, we still need to eat something to satisfy our hunger as well as give us our daily supply of energy. If w...
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