Also Dr. Cane. I'm told that some people can do little (to nothing) to increase their HDL due to genetics within their family. Is this true? If so, should I still take Niaspan? My HDL has never gone over 40....ever. It normally runs between 32-37. Exercise does not seem to help at all. I know nothing about HDL levels in my parents, sisters, etc. They are all gone now.