Chronic Fatigue Syndrome: A HealthCentral Explainer

CRegal Editor

    "I think I have diagnosed myself with Chronic Fatigue Syndrome – I am always tired."


    Unfortunately, the name of the condition can be misleading.  Though "chronic fatigue" is a symptom that does define the condition, there is much more to the syndrome--officially called myalgic encephalomyelitis – than often being tired.


    What Is ME/CFS?


    This  is an autoimmune disease characterized by profound and prolonged exhaustion.  Rest does not relieve the symptoms, nor is it necessarily tied to another illness or condition. 


    CFS was formally defined in 1988 and its relative newness means much still needs to be learned about it. As research improves and more tests are done on patients with the disease, scientists will hopefully be better able to explain the cause of this debilitating condition and how to prevent it.

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    What do people with ME/CFS feel?


    Defining the condition by "fatigue" often  leads to misunderstanding.  Rather than simply feeling tired, CFS victims suffer unceasing  flu-like symptoms, a sense of physical exhaustion that may last for days or weeks and is not relieved by sleep. 


    In order to qualify for an official diagnosis, patients need to have four or more of the following symptoms present for at least six months: impaired memory or concentration; extreme, prolonged exhaustion and sickness following physical or mental activity; sleep that fails to refresh; muscle pain; multi-point pain without swelling or redness; headaches; frequent or recurring sore throat; tender cervical or axillary lymph nodes.


    Who gets ME/CFS?


    Unfortunately, ME/CFS, like many other chronic pain conditions—such as fibromyalgia, TMJ or endometriosis--is difficult to diagnose.  There is no blood test or MRI scan that can be done to identify the condition.  Instead, a doctor makes a diagnosis only after after much observation and testing for other conditions.  It is, unfortunately, a diagnosis-by-deduction.


    It’s estimated that 1 million Americans have the disease, and many more suffer from symptoms but have yet to receive an official diagnosis.  The Centers for Disease Control and Prevention (CDC) estimates that only 20 percent of CFS patients have been diagnosed.


    Studies have shown that nearly 80 percent of ME/CFS patients are women and that they often begin experiencing symptoms in their 40s and 50s.   


    How do you get ME/CFS?


    This is a controversial issue.  Past studies had suggested that the retrovirus XMRV had been identified as the cause of the condition.  The study was then withdrawn due to lab contamination.  FDA scientists have also performed genetic testing on blood samples and discovered similar virus gene sequences in 86 percent of ME/CFS patients, as opposed to under 7 percent of healthy patients. 


    Other studies have shown that childhood abuse can lead to ME/CFS. 


    The CDC identifies possible causes to include infection, immune dysfunction and nutritional deficiency.


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    In April 2012, studies linked ME/CFS to bloodflow issues in the brain.


    So  the jury is still out on the causes of CFS.  It could be one of the aforementioned, it could be several or it could be unrelated to any of these theories.  Only more research will provide answers about this strange and disabling condition.


    What are the treatment options?


    With a not-quite-understood condition comes difficulty with treatment.  There are some prescription medications used for ME/CFS, though they are rarely specific to the condition, as the causes of the condition are largely unknown.  Instead, doctors prescribe antidepressants, antihistamines, anti-inflammatories or anti-virals.  Other drugs can include corticosteroids, immunoglobins or central nervous system depressants.  There are no drugs approved by the FDA for ME/CFS.


    Due to the nature of the disease, there are also a variety of treatment options that can be utilized to help manage the condition.  Acupuncture, aquatic therapy, chiropractics, massage, myofascial release therapy, diet, exercise, meditation and general lifestyle changes (such as allowing more time for rest and creating a more manageable daily routine) can all help with the condition.


    Keep in mind that no two cases of this disease are the same.  Some treatment options will work for some people while others may be completely ineffective.  Choose the program that works best for you and do everything possible to improve your condition. 




    Centers for Disease Control and Prevention.  (15 October 2010).  General Information. Chronic Fatigue Syndrome (CFS).  Retrieved from


    Chronic Fatigue Syndrome – Risk Factors. (n.d.).  A.D.A.M. Medical Encyclopedia.  Retrieved from


    HealthDay.  (24 April 2012).  New Clues to Chronic Fatigue Syndrome.  MedlinePlus.  Retrieved from


    Richards, Karen Lee.  (n.d.).  What Is Chronic Fatigue Syndrome?  Retrieved from


    ScienceDaily.  (16 May 2011).  Childhood Physical Abuse Linked to Chronic Fatigue Syndrome, Study Suggests.  Science News.  Retrieved from


    Wein, Harrison.  (30 August 2010).  Viruses Found in Chronic Fatigue Syndrome Patients.  NIH Research Matters.  Retrieved from






Published On: May 01, 2012