Has anyone ever heard of a condition called (autoimmune Urticaria)? It is a chronic condition known as urticaria hives. What it does from the inside is, your immune system attacks your white blood cells and causes you to be really tired all of the time. I have this and had have quite a few big whelps on me that were a half inch thick and anywhere from 2 to 4 inches in length and 2 to 4 inches in width. They show up just anywhere on your body and the 2 that I was having trouble with showed up on my lower back and right at the base of my neck and went up to the base of the back of my head. I could not bend my head backwards without feeling like I had something stopping me. They were there for about 4 days then they decided to go away. I am now taking 2 prescriptions for this condition and I still feel awful.