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Abuse Resistant Opioids
Denise Coleman
Thursday, August 27, 2009 at 02:26 PM -
about extended-release opioids
gclem
Thursday, August 27, 2009 at 04:52 PMIt`s about time because for some people like myself it`s not fair that most of us has to suffer because some people want to get high from the pills.
I hate pills and most of all I hate pain and being in bed 24/7 with no kind of life at all.
All because of the people that get high from the pills are messing up my life from pain.
It`s a shame that they are taking it out on the good people that do take the pain pills the right way to have some kind of life.
re: about extended-release opioids
chris101899
Thursday, August 27, 2009 at 05:15 PMI'm a person like you, with extreme chronic pain. Two operations, acupuncture, magnets, physical therapy.....nothing works except pain meds.
Well, guess what? I'm ALSO a person who abuses them. The very definition of pain management is addiction, but not always abuse.
I'm sorry that you're in so much pain and have trouble with your doctor. There ARE doctors who understand better and are more helpful.
As for your comments about the "good people". Hey, I'm a good person. A good person with a problem. I didn't ask for it, I didn't wake up one day and decide, hey this could be fun. It happened. I'm not proud of it, and I'm in NA doing my best every day. If you think being addicted and abusing meds is fun, think again. There is nothing fun about losing your job, your friends, your family. And don't say that addicts are "weak". It takes strength I didn't know I could ever have to do this each and every day. It's not weakness, it's addiction.
And it could just as easily be you. It's luck of the draw.
So, please. I would never consider making derogatory comments on here about different "types" of people because I don't know what their lives are like. I don't know what led them to where they are now. You might want to consider doing the same. We're not on here to hurt each other.
re: re: about extended-release opioids
zasu
Thursday, August 27, 2009 at 05:49 PMI totally agree. I can see enormous benefits to the kinds of drug mechanisms that are being developed that will hopefully discourage abuse. However, making judgments on people with addiction problems is just plain wrong. Addiction is a disease that causes chronic pain of its own kind. I suggest we show the same understanding to those patients suffering from the disease and consequent pain of addiction as we do for patients suffering chronic pain caused by other diseases and conditions.
re: about extended-release opioids
Anonymous
Monday, August 31, 2009 at 06:40 PMThe majorty of drug abusers never suffered from pain and use the drugs for their mind altering effects and for the sake of useing the drugs for the high and yes I am sure there are people out there who became addicted by accident and that has to suck but what I read was discust over those who did it to themselves.
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Resistant Morphine
V Williams
Thursday, August 27, 2009 at 05:16 PMWhile it may be a step forward, in we the chronic pain patients fight to obtain proper pain management, let me add that those who wish to abuse the meds will still be able to. If a patient takes enough of the time released meds, they will still get their "high". In the long run, I do not see how it accomplishes the purpose.
re: Resistant Morphine
Kelly
Thursday, August 27, 2009 at 06:44 PMThere are a few things that bother me about this. It seems like the opiate pain relief will terminate as soon as the pill dissolves to the core. Can they really control which med gets delivered at which time.
The second thing is the introduction of another medication into pain sufferers regimen. We all know that every medication causes side effects so who know how the naltrexone will affect us.
I take my meds as directed and I am opposed to the new med.
re: Resistant Morphine
Ihurtalways
Thursday, August 27, 2009 at 08:16 PMI agree with you! People that want to abuse drugs WILL find a way around the "new" morphine that is supposed to be abuse proof. Personally I hate morphine, it makes me feel like shit and I don`t get the pain relief from it (in pill form) that it is supposed to do. My doctor has me on methadone and it works for me, without making me feel "screwed up" or high. But I`m also on small doses of oxycodone for "break through" pain.
I feel that the REAL problem is the government interfering with the doctor/patient relationship and the DEA harassing doctors that are compasionate. I don`t care if some jerk out there wants to get high. As far as I`m concerned, let them. Prohibition does NOT work anyway.It just wastes MORE tax payer money and creates more problems than it stops.
re: re: Resistant Morphine
yeti105
Friday, August 28, 2009 at 04:16 PMi too am like you morphine does nothing for me but the methadone,oxycodone mix with an implanted baclofen pump i actually felt like a "real" person in about 6 yrs or so. i recently was legally disabled put on medicare and that stopped the "me feeling like a real person thing" i was on enbrel for RA,medicare does not cover such expensive meds then my new rheumy says oh you don't have RA. well why then did i feel GOOD,good enough to be a part of my family again while on the enbrel? but i just wanted to say i am glad there is someone else out there that is on methadone for pain,so many people think it is just for junkies trying to get off heroin. good luck hope it keeps on working.
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Embeda
Anonymous
Thursday, August 27, 2009 at 07:46 PMIs this medication only going to be available in the US or will it also be available in Canada? I have Fibromyalgia and Osteoarthritis in both knees and various parts of my body. I am currently on four medications: Lyrica, Percocet, Mobicox and Restoril. At the rate that I am presently going I am going to end up on some more "heavy duty" pain medication and am concerned with addiction and the horrible side effects of those. I tried Oxycontin after I had Arthroscopic surgery and was horrified with the side effects. It did work very well for pain relief but I felt like a zombie both mentally and physically.
I know too many people who abuse opiate medications and am sick and tired of the bad name that people who have chronic pain issues get because of this. I hope that this new medication will be available in Canada and soon!
re: Embeda
Ihurtalways
Thursday, August 27, 2009 at 08:39 PMI also have fibromyalgia and osteoarthrits. Lyrica did nothing for me and neproxen which worked made my guts bleed. I had to stop taking it because I would have bled to death internally! I would suggest asking your doctor about methadone. It works, for me without making me feel screwed up. I`m still in pain but at least I don`t feel like commiting suicide or screaming and crying or worse. And most days I can function, like mowing the lawn, etc..
re: re: Embeda
Anonymous
Friday, August 28, 2009 at 12:36 AMThat is horrible!!! I find that they Lyrica controls a lot of neuropathic pain and if I don't take it I can't even walk without feeling like I am walking on shards of glass and my hands tingle like mad as well.....I was on Naproxen for about a year and change and because I always ate before I took it, it never bothered my stomach very much. Luckily my doctors put me on the coated one as soon as I told them I was concerned about my stomach......I get shots of Marcaine in my upper back and neck twice a week and also will be starting to get more trigger point injections in my elbows due to a lot of shooting pains going down my arms at times. I just hope that this new medication will be available here in Canada ASAP! I don't want to increase my dose of Percocets much more than what I am currently taking due to the fact that I am concerned about liver damage ( I have been on them off and on for about three years now) Oxycontin scares the living bejesus out of me.....I was on Zytram for about a year and it worked wonders for me so maybe I should go back on that and maybe back on Cesamet......who knows! I asked my Rheumatologist about Vicoden and he gave me the evil eye......so that ended there!
re: re: re: Embeda
Ihurtalways
Friday, August 28, 2009 at 11:11 PMI`m glad that Lyrica works for you! I was hoping that it would work for me too, but I have (also) the problem of drug interactions or (I`m not sure what to call it) but alot of prescribed drugs I can`t take because they screw up my body in one way or the other. I get really frustrated at times! And sometimes I feel like the best thing I could do is go out in the woods, dig a hole, jump in it and end it........ BUT- I`m not that bad YET! Close at times but I`m not "there" yet... I just wish that research would hurry up.
re: re: Embeda
Penni
Monday, August 31, 2009 at 09:53 PMI also suffer from fibromyalgia,and nothing seems to work as it should.I hurt no matter what I;ve tried for almost 12 years,now.For the last couple of years I've been taking hydrocodone..7.5,but I still hurt.What it DOES do is allow me to function at work...MOST of the time.It's been pretty bad lately,and I'm wanting to stay in bed for hours again..12-24..at a time because I have NO energy and I hurt too bad to do all the things I should.I couldn't take Cymbolta,Lyrica,Celebrex..I've tried them all..believe me,and the Hydrocodone is the only one that has helped.It has no side effects,as far as a "high" like everyone else seems to get from it.Meds effect me totally different from other people,apparently.I am at the point where I need something stronger.I have a life to live and I refuse to lay down.i have a full time job as an Assistant Shift Supervisor at a detention facility,so I have to stay busy.Lots of walking involved...miles on a shift.Right now I'm hurting really bad in my back and bottom and legs.My arms hurt...even my chest lately.I had a cardiac workup a few weeks ago and it was ok.Fibromyalgia is,as my Dr. puts it,a monster!!I hate it!!ANY advice on a stronger med proven to work?This sounds good..I'm going to ask my Dr. about it.Tylenol...Naproxen...waste of time.
re: re: re: Embeda
Ihurtalways
Tuesday, September 01, 2009 at 11:52 PMI was on neproxsen for about 6 months, it worked very good, I almost felt "normal" till I noticed one day that I was shitting digested blood! I had to stop taking it or I would have bled to death internally. The side effects sometimes are worse than what you are trying to cure... Some times I wish I was a horse, then I`d just get "put down" and I wouldn`t have to bother with it any more!
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It's about time!
Jean
Thursday, August 27, 2009 at 10:43 PMI am so glad King Pharmaceuticals has developed this. Now doc's can feel more at ease in prescribing a drug for those of us who need something more potent without worrying about abuse. I just hope it doesn't cost and arm and a leg! New an innovative drugs usually do and make it cost prohibited for folks like me who live on a fixed income, regardless of the Medicare Rx Plan I have.
I have lived with chronic pain from having a coccygectomy on 2-14-06. My quality of life is not so great, however, I continue to help care for my 89 yr old Mom along with my sister. Mom is not bedridden, but is almost stone deaf and partially blind. We have a lot on our plate dealing with her and our own physical problems. Regardless, we have our faith that keeps us going, prayer, and love and respect for each other. I suppose we are all the better for it. We are a determined lot!
God bless all who suffer chronic pain.
MarJe
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Abuse Resitant Morphine
private
Thursday, August 27, 2009 at 10:52 PMI have been suffering low back pain since about 1997. In May 2006,I had a four level lumbar fusion which did help my pain in that area but as a result,I am now suffering from post-operative pain. Extremely bad pain at times. I currently take 10mg methadone every 6 hours and 15mg oxycodone every 4 hours as needed.Also,2mg alprazolam every 4 to 6 hours as needed for muscle spasms.I am not supposed to lift more than 15 pounds and it kills me to ride very far.I am also on SS Disability.Took me 2 and a half years to get it.I don't abuse my medications.I understand and admit that I am physically dependent(having been on narcotics since 2005).But I'm not an addict.There is a difference between the two.Addicts take more of their meds than prescribed.This new medication may be helpful to these patients who cannot control their addictions. As for me,I HATE the fact that I will be on narcotic pain meds for the rest of my life.I have to take one of my oxycodone tablets just to get out of bed.I used to be a very outgoing and active person.Now I'm homebound and wasting away at 46 years of age.Living on narcotic meds is no picnic.A couple of years ago when I was taking 40mg Opana ER twice daily and 10mg Percocet 8 times daily someone told me how "lucky"I was.I was suffering very badly at the time.How ignorant and just plain stupid can someone be? It is not "lucky" to be sick.I don't even enjoy life like I once did. Anyway,sorry to get off the subject,but had to get it out. Anyone in bad enough pain (even addicts)deserve pain relief. Hopefully,the doctors will consider it for those who cannot control their cravings for drugs.As for me,I cant take morphine due to side effects and most importantly,I follow my doctor's orders. The only "lucky" thing about my ordeal is I'm not an addict.re: Abuse Resitant Morphine
Anonymous
Saturday, August 29, 2009 at 10:38 PMThere are some people out there including doctors who are INSENSITIVE JERKS!!! Need I say more...I hope that someday scientists will be able to find medications that will help many people out there who are in chronic pain day in and day out......I feel for you and for all others out there who are in the same situation that we are in.....I posted a couple of comments recently in regards to Embeda and I would love to be able to take that medication even just at bedtime so I can get some sleep. I am kept awake most nights because of pain and it stinks!!!
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Abuse-Resistant Morphine Approved prepare to be guinea pigs.
DSuperDave
Friday, August 28, 2009 at 03:33 AMAlthough this is a good idea for certain situations, I still have some concerns and reservations about this medication. As stated earlier, if someone wants to abuse drugs, they will. I really don't see this helping that much in that particular area. However I do see this helping with the uninformed (teenagers, grandchildren, etc.) if they are unaware, then I can see this being very beneficial.
My concerns as with any new medicines are what will happen in the long run. Many medicines that I have taken in the past are getting relabeled for problems or side effects and some have been pulled altogether. My understanding of Naltrexone-Hydrochloride is that it binds with the same receptors in the brain as the morphine-type of pain killers do. This blocks the morphine receptor from being able to bind with the morphine. This could potentially be very bad for a pain patient. I believe I have read somewhere that it's one of the main drugs to help addicts of morphine type-addictions to help give up their addiction. With this in mind, I have several questions.
If we as patients follow directions, is there any way to guarantee that the Naltrexone will not accidently release or partially release while we're taking it? If it did release even a small quantity of Naltrexone would this reduce the effectiveness of any Morphine-based medication? How long does the Naltrexone bond or "effects of blocking" last? Could there be any permanent receptor damage with this?
I know this sounds like I'm against this medication, but I'm not. I have spent many years in severe, uncontrolled pain since the mid 1990's. I started out with having constant infections in my sinuses, ears, bladder, testicles, epididymis, and a few others. For the first couple of years I was treated over and over with Levaquin. After months of being on this and other medications they surgically removed my epididymis and the infections slowly dissipated over the years but the pain had begun to get worse, a lot worse. I began losing jobs and could not even finish my part-time college pursuits. I finally gave-up after having sinus surgery in August, 2004 after having sinus surgery. My pain was out of control and I just couldn't work anymore. I actually couldn't do much of anything anymore. To cut this story short. I filled for disability in 2005 and have yet to be approved. Our world has fallen apart due to my pain. It seemed like I had tendonitis all over my body. Almost every muscle was sore or in pain.
Now I have read that there was some kind of recall on the antibiotic Levaquin due to it causing many types of tendon damage. The same medicine that I was given recurrently and depended on for clearing up the many infections. Since then I have been diagnosed and I am presently being treated for many illness including hypothyroidism, Vertebra damage consisting of stenosis, arthritis, herniated discs in neck and upper and lower back, nonalcoholic-steatohepatitis with hepatic necrosis, fibromyalgia, depression and the list goes on... and so does the medications.
As you can see, I'm very hesitant to jump on the band-wagon of something that for myself, I feel is unnecessary anyway. I hope they allow the regular morphine to remain available until there's no doubt that the new stuff works as stated without any side-effects.
And for those of you wondering, no, I haven't contacted a lawyer on the possibility of having a lawsuit against the makers of Levaquin. Heck, I can't even get SSDI and I've had a lawyer for several years for that so why bother. I'm just happy to finally have a pain management doctor who helps me.
Good night all. SuperDave McDaniel
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EMBEDA
mcshortcake
Friday, August 28, 2009 at 10:23 AMFinally, I have been taking Ms Contin 15mg, Morphine Sulfate(s) 30mg, and 60mg. since the year 2000.

I have chronic fibromyalgia. I CANNOT take Lyrica. It blows up my feet, and blurs my vision, and that really sucks, because it really helps my pain. I also take neurontin, and flexeril for the F.M. I am going to e-mail my pain management specialist, and see if we can discuss this.
re: EMBEDA
Ihurtalways
Friday, August 28, 2009 at 11:35 PMOne thing I know for sure is that talking to the doctor is good. Unless your talking about chronic pain! You have to be VERY carefull about what you say, if you are talking about being in pain all the time. Some times I wish I had just died when I got hit by a car doing 40 MPH. I wouldn`t be in pain now... I hope you find the right thing to make you feel better and I wish a pain free day for everyone!
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Good article
Megan Oltman
Thursday, September 03, 2009 at 11:06 AMKaren - this is good news and a good treatment of the topic. I linked to your article in a blog post at The Miracle of Pharmaceutical Engineering.
Keep up the good work - i love reading your articles.
- Megan
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Thank you for this informative Post. It is good news that pharmaceuticals are exploring ways to reduce the abuse of these strong pain medications without doing so at the expense of people living with pain. Is there any report on the overall effectiveness of this medication for severe chronic pain? Will people in chronic pain get the same level of relief they are now getting from opioids such as OxyContin? Perhaps only time will tell but it is a positive step that I hope other pharmaceutical companies will follow in regard to other pain medications that some people not living with pain abuse.
I have written several Posts about the intrathecal pump that I have had since January 2000 and the tremendous pain relief I have gotten from the Morphine, Bupivicaine and Baclofen it delivers directly to my Central Nervous System. The pump is completely implanted in my abdomen and dosage or rate of delivery cannot be altered except by the doctor using a specialized piece of equipment. I have the pump filled every 6 or 7 weeks and receive a constant flow of medication on a 24/7 basis. I realize this is not the answer for everyone, or for all kinds of pain, but after 37 years in pain and trying every possible kind of medication and treatment, the pump was a welcome relief.
I am pleased that pharmaceuticals are taking seriously the threat of having access to opioids limited for pain management and hope we will see additional options offered, including enhanced information and use of the intrathecal pump in cases where it is appropriate. Thank you, Denise