Is their one Drug that actually works?

Has anyone found any drug that actually reduces pain enough so that you can have any kind or semblance of a normal life? Morphine is not helping.

Background: 47 y/o male. Post right total knee replacement 14 months ago now painful with movement. Post: laminectomy X4 with Lumbar Fusion X4, L3/L4 L5/S1. 8 turnbuckles, 8 three inch screws and 8 rods and the implant.

Meds: Duragesic 300mcg. Patches Q72 hours W/ Percocet 10/325 for BTP.

         Changed to MS Contin 300 Mg BID...

I tried Fentora 10mg bucci with nothing but lightheadedness  so stopped them.

What's working for you?