New FDA approved medication for Fibromyalgia.

VanessaK Community Member July 31, 2007
  • Today I received information from the Prescriber's Letter (a pharmicological newsletter) about a new medication FDA approved for Fibromyalgia.  It is called Lyrica.  However, results of clinical trials showed only modest efficacy in pain relief compared to placebo.  In addition, this efficacy can decrease after weeks or months.  Lyrica has already been used for neuropathic pain and partial onset seizures.  The exact mechanism of action of Lyrica is unknown. It is proposed that the binding to the alpha-2-delta subunit of the calcium channel decreases calcium influx at nerve terminals and reduces the release of several neurotransmitters, including glutamate, norepinephrine, and substance P. Simply put, it stops the neurotransmitter release which results in pain relief.

     

    Studies showed that only about 28% of patients experienced a 50% reduction of pain.  For 25% of patients that experienced pain relief, they loss that relief after a month. Also they say that a dose of Lyrica ranges from 75mg twice daily to 225mg twice daily but the higher doses don't generally see an increase in pain relief just an increase in side effects, although a few people who took the drug at the higher doses did see a further decrease in pain.  A few of the most common side are sleepiness, dizziness and "brain fog".  Keep in mind this drug is new for treatment of fibromyalgia and has not been studied beyond 6 months.

     

    I don't want to sound negative about this new drug, I am just repeating what is given in the newsletter.  They recommend this drug only as a second and third line drug, to use only when other treatment fails.  I hope this information helps and I truly hope if you try Lyrica, it works for you. 

2 Comments
  • annebeckett
    Aug. 20, 2007

    Guess I missed it as I had finally had my jaw-joints removed the day before you posted...

    Anyway, back to your post:  I'm GLAD you made note of the plusses AND negatives re: Lyrica.  It seems that all else we have heard on this drug is how wonderful it is.

    Personally, I tried Lyrica..;  for about 10 days.  Then, I began to have severe...

    RHMLucky777

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    Guess I missed it as I had finally had my jaw-joints removed the day before you posted...

    Anyway, back to your post:  I'm GLAD you made note of the plusses AND negatives re: Lyrica.  It seems that all else we have heard on this drug is how wonderful it is.

    Personally, I tried Lyrica..;  for about 10 days.  Then, I began to have severe chest pain.  After reading all of the literature included in my (thankfully) sample bottle of the drug, found out that those of us who had had serious heart problems in the past ought NOT take Lyrica.  Well, I had Rheumatic fever and Rheumatic Heart Disease as a child... hmm;  I stopped the Lyrica and the chest pain soon abated.

    We DO need to make note of ALL possible problems and precautions posted and weigh the pros and cons for ourselves, PERSONALLY.  Not everyone can or should take the same drugs and my body is one certain indicator of that!

    Thanks again for your post.

    Anne

    • VanessaK
      Aug. 20, 2007

      Anne,

       

      Thanks.  Not everyone likes to hear the cons of a new "wonder drug".  I am glad you stopped the drug before you began having serious heart problems.  I wish you all the best.  Vanessa