Hi, I have all that you named above, plus 2 knee replacements, chronic DVT (blood clots), and severe migraines. I also had surgery on my neck and bone was taken from my hip to fix my C-3 and C-7 discs, and an "E" metal devise to hold discs in place. That was done in 1995. I ended up retiring in 1998, cause I could not sit at the computer anymore. I take "Kadian 80 mg" twice a day, oxycodone 30 mg, 4 times for breakthrough. My recent knee replacement was on 9/30/08. I am also opiod tollerent, from being on pain med.'s for years. I totally understand how you feel. I hope you get some help. nwichet