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Sunday, May 11, 2008 lab71, Community Member, asks

Q: how long does a percocet 10 mg stay in your blood system?

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Answers (1)
Karen Lee Richards, Health Guide
5/12/08 5:21am

The oxycodone portion of percocet has a half-life of 3.2 hours for the regular version and 4.5 hours for the extended release version.  (The half-life of a medication is the time it takes for your body to metabolize and excrete a drug so that half of the drug is removed from your body.)  As a general rule you are considered fully clean in blood and urine after 5 half lives. So for regular percocet, that would be 16 hrs. and 22.5 for extended release. 


Keep in mind that the half of every drug varies greatly.  Half-life can also vary from patient to patient if the patient suffers from altered kidney or liver function.  For a more accurate estimate for a specific medication, check with your pharmacist. 



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By lab71, Community Member— Last Modified: 04/04/14, First Published: 05/11/08