oxycodone 15 mgs has no acetametophen in it. It is much better for your liver and kidneys. But it is very strong. I think i spelled wrong. But you know what i mean . 5 10/325 is alot for a liver and kidneys to handle. You wont risk damage to those organs on oxycodone 15mgs. And you probably wont have to take as much. It works really good. But it is strong, so be a little careful. Hope this helps. Good luck, have a nice night.