Please take your wife to the doctor. Unexplained heap pain should always be checked out by a doctor.
Nobody can give you a solution or tell you what the problem is on the Internet. The only person who can do that is a doctor who reviews her medical history, discusses her symptoms with her, and examines her in person.
From what you've said, this could be any number of things. Considering the nose bleeding it could be a headache caused by high blood pressure. It could also be Migraine, but only a doctor who sees her can tell you.
Good luck to you and your wife.