On Monday, the pharmaceutical company Zogenix, Inc. announced the FDA had accepted for review their New Drug Application (NDA) for Zohydro ER™ (hydrocodone bitartrate extended-release capsules).
Hydrocodone is one of the most frequently prescribed opioid drugs for the management of moderate to severe chronic pain. There are, however, two features that set Zohydro ER apart from other hydrocodone products currently available:
It does not contain acetaminophen.
It is an extended-release medication.
Other hydrocodone medications currently available (like Vicodin and Lortab) all contain acetaminophen , which can be hard on the liver. They are also all immediate-release, meaning they have to be taken every four to six hours. Zohydro is intended to be administered every 12 hours to provide round-the-clock pain management for an extended period of time.
Under the Prescription Drug User Fee Act, the goal for a standard review of an NDA is 10 months from NDA subm...
Generic Name: HYDROCODONE/IBUPROFEN - ORAL Pronounced: (HYE-droe-KOE-done/EYE-bue-proe-fen) Hydrocodone-Ibuprofen Oral Interactions
Drug interactions may change how your medications work or
increase your risk for serious side effects. This document does not contain all
possible drug interactions. Keep a list of all the products you use (including
prescription/nonprescription drugs and herbal products) and share it with your
doctor and pharmacist. Do not start, stop, or change the dosage of any
medicines without your doctor's approval.
Some products that may interact with this drug
aspirin or other NSAIDs (such as ketorolac,
anti-platelet drugs (such as cilostazol,
bisphosphonates taken by mouth (such as
"blood thinners" (such as enoxaparin, heparin,
corticosteroids (such as prednisone)
MAO inhibitors (isocarboxazid, linezolid, methylene blue,
While most drugs are designed for specific uses, gabapentin (Neurontin) is a drug of many uses. Anti-biotics are used to treat infections. Hypertension is treated with blood pressure medication. Anti-emetics relieve nausea. The list goes on and on about specific drugs and what they are intended to do. Although a few, like gabapentin, are used for a multitude of problems. Gabapentin was originally designed to treat seizures. Its usefulness keeps expanding into other areas for the treatment of pain, anxiety and addiction.
For years, gabapentin has been a valuable tool for the treatment of pain, specifically neuropathic pain. This drug calms painful nerve impulses in conditions like diabetic peripheral neuropathy, phantom limb pain and sciatica. But its usefulness for the treatment of pain goes beyond the nerves .(1) Even cancer-associated pain and surgical pain respond to gabapentin. If someone does not tolerate this drug because of side effects like drowsiness or dizziness, other...
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