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Topamax (topiramate) is a neuronal stabilizing agent (aka anticonvulsant medication) that is FDA-approved for and prescribed for headache and Migraine prevention. Researchers at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern) have completed a study showing that Topamax can increase the propensity for calcium phosphate kidney stones. Although there has been anecdotal evidence of this potential side effect and much discussion of it, this is the first study to formally investigate the issue and examine the mechanism of stone formation. "The wide-spread and escalating use of topiramate emphasizes the importance of considering the long-term impact of this drug on kidney-stone formation," said Dr. Khashayar Sakhaee, senior author of the study and chief of mineral metabolism at UT Southwestern. Study methods This was a two-phase study: Phase 1: Thirty-two patients treated with topiramate and 50 healthy volunteers participated in a cross se...
Need another reason for getting more physical activity in 2014? It turns out that just a little bit of activity may protect older women from developing kidney stones. And that’s important since, as I noted in a May sharepost , postmenopausal women have an increased risk of developing these potentially painful stones.
So first, let’s jump to the research. The study out of the University of Washington’s School of Medicine involved 84,225 women who had no history of kidney stones. These women were participants in the Women’s Health Initiative Observational Study, which was a longitudinal study of postmenopausal women. This study enrolled the women between 1983 and 1998 and then followed them for approximately eight years.
The researchers’ analysis found that the risk of kidney stones was 16 percent lower in women who had the lowest physical activity level when compared to women who were not physically active. Furthermore, as women’s...
A friend of mine who is well past the menopause transition recently let us know that she wasn't feeling good. She complained about a severe pain in her abdomen, eventually contacting her health care provider. Eventually, the pain went away and she now believes that she passed a kidney stone.
After doing a little research, I learned some that postmenopausal women do have issues with kidney stones. Current estimates are the kidney stones affect between 5-7 percent of U.S. postmenopausal women. And a 2010 study out of the University of Texas Southwestern Medical Center found that the use of estrogen therapy by postmenopausal women might increase the risk of developing kidney stones by approximately 20 percent.
What Are Kidney Stones?
The Mayo Clinic reports that kidney stones are not linked to one definitive cause. They form when urine contains more crystal –forming substances (uric acid, calcium and oxalate) than the fluid in the urine can dilute. Furthermore, the ur...
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