FROM OUR EXPERTS
This question has not been answered by one of our experts yet.
Topamax (topiramate) is a neuronal stabilizing agent (aka anticonvulsant medication) that is FDA-approved for and prescribed for headache and Migraine prevention. Researchers at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern) have completed a study showing that Topamax can increase the propensity for calcium phosphate kidney stones. Although there has been anecdotal evidence of this potential side effect and much discussion of it, this is the first study to formally investigate the issue and examine the mechanism of stone formation. "The wide-spread and escalating use of topiramate emphasizes the importance of considering the long-term impact of this drug on kidney-stone formation," said Dr. Khashayar Sakhaee, senior author of the study and chief of mineral metabolism at UT Southwestern. Study methods This was a two-phase study: Phase 1: Thirty-two patients treated with topiramate and 50 healthy volunteers participated in a cross se...
Complications Between 70 and 90% of crystals remain tiny enough to travel through the urinary tract and leave the body in the urine without being noticed. When they do cause symptoms, however, kidney stones have been described as one of the most painful disorders to afflict humans. The pain they cause is sometimes called renal colic . ("Renal" means "kidney.") Effects on the Urinary Tract and Kidneys Obstruction and Infection. Although kidney stones often lead to obstruction (blockage) of the urinary tract, the blockage is usually temporary and causes no lasting damage. In some cases, however, particularly if the obstruction progresses with no symptoms, infection may occur, which can be serious and need immediate attention. Chronic Kidney Disease . People with kidney stones face a higher risk for chronic kidney disease, particularly if they also have diabetes, high blood pressure, or frequent urinary tract infections. Kidney Failure . It is very rare for kidney stones to cause kidney failure....
A friend of mine who is well past the menopause transition recently let us know that she wasn't feeling good. She complained about a severe pain in her abdomen, eventually contacting her health care provider. Eventually, the pain went away and she now believes that she passed a kidney stone.
After doing a little research, I learned some that postmenopausal women do have issues with kidney stones. Current estimates are the kidney stones affect between 5-7 percent of U.S. postmenopausal women. And a 2010 study out of the University of Texas Southwestern Medical Center found that the use of estrogen therapy by postmenopausal women might increase the risk of developing kidney stones by approximately 20 percent.
What Are Kidney Stones?
The Mayo Clinic reports that kidney stones are not linked to one definitive cause. They form when urine contains more crystal –forming substances (uric acid, calcium and oxalate) than the fluid in the urine can dilute. Furthermore, the ur...
You should know
Answers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Content posted by community members does not necessarily reflect the views of Remedy Health Media, which also reserves the right to remove material deemed inappropriate.