Friday, October 31, 2014

Monday, September 06, 2010 Kathleen, Community Member, asks

Q: I currently take generic NORCO 10/325. If I were to switch to Hydrocodone-APAP 10/650, would I get more pain relief?

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Answers (3)
Scooter, Community Member
9/ 6/10 1:11pm

The only difference between the two is the amount of acetaminophen. It would be better to just stick with the Norco. Having all the extra acetaminophen just makes it worse for your liver. Good luck.      Scooter

Penelope, Community Member
9/18/10 10:43pm

I have taken this before.  The only brand that worked at all for me Ameal or Ammeal.  The other brands did not work!

Also the Ameal is a generic, believe it or not.  As far as the 10/650 Vicodin, I would never give up percocet for these!  Also, you would get 650mg of tylenol, verses the percocet with only 325mg.  The codine is the same on both.  So no, I would not advise you to switch to the Hydrocodone, maybe just try the Norco/Ameal brand or swith to oxycodone without any tylenol.  Why do you need tylenol?  Tylenol is worst for you than the codine is.  Also if  you were to switch to something without  tylenol, starting out with a lower dosage, you would probably have to take less, and not feel the tired feeling that tylenol gives you.  If it is swelling or inflamation you suffer with, a small amount of Ibuprofen, like 200mg taken with your plain oxycodone will help a lot better than tylenol, if you are not allergic to Ibuprofen.  For me, the best combination for myself is, oxycodone taken with 10mg of methodone.  I have to pay, and see a pain specialist for this though. Before I started taking methodone though, I took sometime, an 200mg ibuprofen, not too many ibuprofen though, because this will make you feel tired.  At night ibuprofen helps you to rest better too!  Please, as I did, ask your Doctor before you take anything or mix it with what He is giving you, even over the counter medicine. 

God bless you, and good luck!!! 


I  spelled the brand name of the percocet wrong. The correct spelling is, Amneal. Also codiene was wrong also.  I hope I spelled codiene right this time, my dictionary is mislocated at the present.  Forgive me, this has been a long, and very hot day.  I had to drive over 40 miles myself to my pain Doctor, and was in a hurry when I wrote that.  I just want to help everybody that I possibly can, that's all! 


God bless you!  Do become well, and feeling better much soon! 



JCREW, Community Member
1/13/11 2:47am

there is absolutely no difference between the two except that norco is just a brand name of hydrocodone and it has only 325 mg of acetaminophen. In my experience, the norcos are way more effective than generic hydrocodone. However, acetaminophen potentiates or increases the effectiveness of hydrocodone and all other opiates, so if you can get vicodin 10mg it may be better for you. It all just depends on your tolerance for tylenol (acetaminophen). As for me, i have a ridiculously huge tolerance for tylenol because i have taken large amounts of the stuff throughout my life to combat frequent migraines, so i prefer norcos. I also prefer norcos simply because tylenol seriously ravages the liver, so the less of that stuff you take, the better off you are. I dont know how many norcos you take in a day, but you should never take more than 2,000mg of acetaminophen in a 24-hour period as liver damage is likely if you take more than that. I am assuming you probably take a norco every 4-6 hours, so that's about 4-6 norcos a day or 1,300-1,950mg of acetaminophen a day. If you switched to hydrocodone 10/650, you would be taking 2,600-3,900mg of acetaminophen in a day, which is WAY too much and could eventually result in considerable damage to your poor old liver. Take my advice for what it's worth, and stick with the norcos. They are better at alleviating pain and are a healthier choice all around. Or just switch over to percocet 10/325 (oxycodone 10/325) and you will get way more pain relief, cause trust me, percs are WAAAAAAY better than nasty old vics. Hope you get it all figured out and my advice helped you make your decision! Good luck Kat :-).

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By Kathleen, Community Member— Last Modified: 04/09/14, First Published: 09/06/10