Studies show that joint laxity (loose ligaments) in the knee can lead to anterior cruciate ligament (ACL) rupture. In this study, researchers look to see if patients with excessive joint laxity have different results after ACL surgery depending on the type of tendon graft used to repair the rupture. Two groups of patients were compared. Everyone had an ACL tear and needed reconstructive surgery. The first group had normal joint laxity. The second group had generalized joint laxity (present in all the joints). Two different types of standard tendon grafts were used in both groups (hamstring graft and bone-patellar tendon-bone graft). It was expected that the patients with joint laxity would have different results depending on which type of graft was used. One surgeon did all of the operations. The surgical technique was described for both grafts. Everyone had the same postoperative rehab program. X-rays were taken before and after the procedure. The images were uploaded to a special compu...
Recently, the pharmaceutical company Amgen (the makers of
Enbrel ) announced that the results of a Phase 3 trial had been published which
studied the drug denosumab in postmenopausal osteoporosis.
Denosumab treatment significantly increased bone density in
the lumbar spine compared to placebo, in addition to the hip, the wrist and the
total body. In another study, the drug also seemed to protect bone from erosion
in rheumatoid arthritis patients.
Denosumab is a monoclonal antibody which targets RANK
Ligand, a cell mediator that break down bone. RANK Ligand is found in many parts of bone.
What I find interesting is that Amgen is also looking at the
effect of denosumab on bone erosions in rheumatoid arthritis in a Phase 2
study. RANK Ligand-driven osteoclast
activity — osteoclasts being those cells which erode the bones — has been
implicated in the destructive bone erosions which are characteristic of rheumatoid
arthritis and other forms of er...
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