FROM OUR EXPERTS
Fractures, or breaks, of the tibia (shin bone) are the most common type of break in the longer bones of the human body. These fractures can be clean breaks with little or no bone movement or they can be severe breaks that also cause damage to the muscles, blood vessels, nerves, and body tissues around the broken bone. When the tibia is broken in the bottom third of the bone (closest to the foot), after healing, there is a higher chance of the bones not lining up properly. In fact, this happens in about 84 percent of cases. The most common of these is when the farthest part of the bone moves away from the midline of the body. Unfortunately, this can be difficult to treat. To fix this type of fracture, one type of repair the surgeons use is a special type of nail to join the broken bone parts. Part of the bone can be quite wide, however, making it difficult for the nail to be stabilized in the bone. This leads to the bones not lining up properly again. As well, because the lower leg moves...
If you've ever had a broken bone, you know that there are several ways to repair the fracture. One way is to splint or cast the bone and wait for it to heal on it's own, or if the fracture is complex, surgery may be necessary where the option's for internal fixation would be, rods and screws, plates and screws, or pins and wires, and some require bone transplantation obtained usually from the hip (iliac crest) to fill the non union portion of the fracture. All of these approaches, aside from casting, involve surgery, a hospital stay of several days, physical therapy, bone graft site and surgical site healing.
When your surgeon harvests bone from your hip, an incision is made above the bone and then they extract and collect the bone with a drilling device. This approach has to heal just like the fracture repair portion and sometimes problems occur, like bone infection, delayed incision healing, and additional pain from the process of removing the necessary bone from your hip to ...
Recently, the pharmaceutical company Amgen (the makers of
Enbrel ) announced that the results of a Phase 3 trial had been published which
studied the drug denosumab in postmenopausal osteoporosis.
Denosumab treatment significantly increased bone density in
the lumbar spine compared to placebo, in addition to the hip, the wrist and the
total body. In another study, the drug also seemed to protect bone from erosion
in rheumatoid arthritis patients.
Denosumab is a monoclonal antibody which targets RANK
Ligand, a cell mediator that break down bone. RANK Ligand is found in many parts of bone.
What I find interesting is that Amgen is also looking at the
effect of denosumab on bone erosions in rheumatoid arthritis in a Phase 2
study. RANK Ligand-driven osteoclast
activity — osteoclasts being those cells which erode the bones — has been
implicated in the destructive bone erosions which are characteristic of rheumatoid
arthritis and other forms of er...
You should know
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