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Friday, April 03, 2009 Tisha, Community Member, asks

Q: Naproxen 500 mg. How many can you safely take at one time.

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Answers (1)
Karen Lee Richards, Health Guide
4/ 4/09 1:27am

500 mg is the most that should be taken at any one time, with a maximum of 1500 mg per day.  It should not be taken on a regular basis for more than 6 months.


Naproxen has some pretty serious black-box warnings on it, so it's important not to take any more than necessary and to use it for the shortest duration possible.  Following are the black-box warnings: 

Cardiovascular Risk:
Naproxen may increase the risk of serious and potentially fatal cardiovascular thrombotic events, myocardial infarction, and stroke; risk may increase with duration of use; possible increased risk if patient has cardiovascular disease or cardiovascular disease risk factors; contraindicated for Coronary-Artery Bypass Grafting Surgery peri-operative pain.

GI Risk:
Naproxen increases the risk of serious gastrointestinal adverse events including bleeding, ulceration, and stomach or intestine perforation, which can be fatal; may occur at any time during use and without warning signs; elderly patients are at greater risk for serious GI events.
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By Tisha, Community Member— Last Modified: 06/13/13, First Published: 04/03/09