Can I take Benadryl while taking Vicodin, separately and not on an empty stomach?
Taking benadryl while taking Vicodin could increase the chances of central nervous system and/or respiratory depression. You can read more about this possible interation here: Drug Interaction Checker. It's always better to ask your doctor or pharmacist about drug interactions like this, since they are more likely to know your medical history and how you may react to the drugs.
Here are some articles on pain medications from our site that you might find useful:
Let’s Talk Pain Meds
What You Didn’t Know About Pain Meds
Give Your Medicine Chest a Check-Up
can i take benadryl while taking vicodin