I would take Savella but it isn't available yet (and who knows for how long) here in the UK. I have heard very good feedback from a few people taking right now in USA.   Not sure about Cymbalta. Someone said it makes you put on weight and I don't want that I am overweight as it is with difficulty getting rid of it since having FM and CFS.   I just take Co-codamol 30/500 about twice a day for pain plus trying Mobic (NSAID) for joints - only helping hands at moment. I take Citalopram for depression and Propranolol for anxiety attacks (as required up to 4 a day). I find Citalopram good not great but much better than some SSRI type ant-depressants. I do think it contributed to the weight gain though.   Regards Lara x